“When there is too much drug in the blood, you may have more side effects.”įor example, if you drink a lot of grapefruit juice while taking certain statin drugs to lower cholesterol, too much of the drug may stay in your body, increasing your risk for liver and muscle damage that can lead to kidney failure. With most drugs that are affected by grapefruit juice, “the juice lets more of the drug enter the blood,” says Shiew Mei Huang, Ph.D., of the FDA.
How Grapefruit Juice Can Interfere With Medications What other fruits or juices may also affect your drug in a similar way to grapefruit juice.How much, if any, grapefruit juice you can have.Talk to your health care provider or pharmacist, and read any information provided with your prescription or non-prescription (OTC) drug to find out: The severity of the interaction can be different depending on the person, the drug, and the amount of grapefruit juice you drink. Grapefruit juice does not affect all the drugs in the categories above. Some antihistamines, such as Allegra (fexofenadine).Some drugs that treat abnormal heart rhythms, such as Pacerone and Cordarone tablet (both amiodarone).Some corticosteroids that treat Crohn’s disease or ulcerative colitis, such as Entocort EC and Uceris tablet (both budesonide).Some anti-anxiety drugs, such as BuSpar (buspirone).Some organ-transplant rejection drugs, such as Neoral and Sandimmune capsule or oral solution (both cyclosporine).Some drugs that treat high blood pressure, such as Procardia and Adalat CC (both nifedipine).Some statin drugs to lower cholesterol, such as Zocor (simvastatin) and Lipitor (atorvastatin).Here are examples of some types of drugs that grapefruit juice can cause problems (interact) with: Food and Drug Administration has required that some prescription and over-the-counter (OTC) drugs generally taken by mouth include warnings against drinking grapefruit juice or eating grapefruit while taking the drug. Grapefruit juice and grapefruit can affect the way your medicines work, and that food and drug interaction can be a concern. Grapefruit has vitamin C and potassium, nutrients your body needs to work properly. Grapefruit juice and grapefruit can be part of a healthy diet.
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